e0118 The myeloperoxidase inhibitor, aminobenzoic acid hydrazide, alters neutrophil-endothelial cell interaction
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چکیده
منابع مشابه
Mechanism of inactivation of myeloperoxidase by 4-aminobenzoic acid hydrazide.
Hypochlorous acid is the most powerful oxidant generated by neutrophils and is likely to contribute to the damage mediated by these inflammatory cells. The haem enzyme myeloperoxidase catalyses its production from hydrogen peroxide and chloride. 4-Aminobenzoic acid hydrazide (ABAH) is a potent inhibitor of hypochlorous acid production. In this investigation we show that, in the presence of hydr...
متن کاملNeutrophil-Endothelial Cell Interaction
Methods Bovine microvascular endothelial cells (MEC) were able to degrade the H202 generated by phorbol myristate acetate-activated bovine neutrophils or by glucose oxidase with a maximal capacity of 4.0±1.2 (SD) nmol/10' cells/min, corresponding to the H202 released by about 3 X 10' neutrophils. H202 degradation occurred via the glutathione redox cycle and catalase. Degradation via the glutath...
متن کاملPhysico-chemical studies of some aminobenzoic acid hydrazide complexes
The stability constants and related thermodynamic functions characterizing the formation of divalent Ni, Cu, Zn, Cd and Hg complexes with oand p-aminobenzoic acid hydrazide were determined potentiometrically at different temperatures. The formations of the complexes are endothermic processes. The formed bonds are mainly electrostatic. Conductometric titration was carried out to determine the st...
متن کاملThe protein phosphatase inhibitor cantharidin alters vascular endothelial cell permeability.
In this study, we characterized the effects of the protein phosphatases type 1 (PP 1) and type 2A (PP 2A) inhibitor cantharidin in endothelial cells. We identified catalytic subunits of PP 1alpha, PP 2Aalpha, and PP 2Abeta immunologically in bovine aortic endothelial cells. Moreover, we detected mRNAs coding for catalytic subunits of PP 1alpha, PP 1beta, and PP 2Aalpha by hybridization with spe...
متن کاملNeutrophil-endothelial cell interaction: evidence in vitro for a regulation by endothelial cells of neutrophil functions.
The purpose of this study was to investigate a possible relationship between human umbilical vein endothelial cells (EC) triggered by ionophore A23187 at different doses (0.5-2.5 microM) and polymorphonuclear neutrophils (PMN). EC supernatants were shown to contain neutrophil chemoattractant activity (NCA) and in parallel a factor inducing an inhibition of PMN chemiluminescence (PMN CL). Supern...
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ژورنال
عنوان ژورنال: Heart
سال: 2010
ISSN: 1355-6037
DOI: 10.1136/hrt.2010.208967.118